Single Cell Genomics Scientist (m/f/d) – Full time / Mainz


We are looking as soon as possible for support in our Clinical Cancer Genomics unit. The successful candidate will contribute to the development of immunotherapeutic treatments against cancer and other diseases by studying immune and cancer cells to understand disease, resistance and immunomodulatory mechanisms

Your tasks and responsibilities:

– Conduct single cell RNA- and single cell TCR-sequencing experiments by using 10x Genomics platform and analyze heterogeneous cell populations

Profile chromatinaccessibility via targeted bisulfite sequencing and perform single cell ATAC sequencing (10x Genomics) for epigenetic studies

Develop and evaluate new technologies and protocols for single cell analyses including cell culture, tissue dissociation, NGS library preparation and bioinformatics data analysis

Plan, implement, document and present research projects and experiments

Cooperate in multidisciplinary teams with other TRON units like Cell culture, NGS and Bioinformatics and external collaborators to plan, design and run experiments

Instruct lab technicians and students

Apply findings in both R&D and clinical projects for biomarkers and immunotherapies with a direct impact on patient health care

What you bring:

PhD degree in Biochemistry, Cell Biology, Biotechnology or related discipline

Profound knowledge in molecular biology, cell biology, and immunology
– Expertise in tumour biology, cardiovascular or autoimmune diseases would be a plus
Experience in molecular methods such as NGS and quantitative PCR is required

Practice in single cell sequencing, epigenetics and mammalian cell culture is beneficial

Knowledge of standardized processes and documentation (SOPs) as well as the creation and maintenance of Quality management/assurance documentation is expected

Any experience with widely used programming languages (R, Python etc.) would be of advantage

Strong visual, verbal, and written communication skills as well as strong sense of responsibility and high reliability are essentia

Enthusiasm and curiosity for the diverse activities of our research institute as well as the ability to work in a team completes your profile.

We offer:

A dynamic, innovative and creative research environment

An open, collegial and cordial working atmosphere in a respectful corporate culture

A high degree of diversity in the workforce

Flat hierarchies
Performancerelated remuneration and other benefits
The opportunity for personalised further training
An excellent transport connection by public transport and car, parking spaces, secure bicycle parking
The opportunity for hybrid working

TRON is an internationally recognised institute for translational research. We combine the strengths of academic research with the requirements of qualitycontrolled industrial developments. At TRON, we share a common mission to develop innovative solutions for the immunotherapeutic treatment of cancer, infectious diseases and other serious diseases with high medicinal need for development.

TRON was founded in Mainz in 2010 and works in close cooperation with universities and hospitals as well as with regional, national and international research institutions and pharmaceutical companies.

As part of our team, you have the opportunity to be at the forefront of translational science with us.

If all this appeals to you, we look forward to getting to know you.

lease send us your complete and informative application documents (cover letter, CV, references) in a single document of max. 5 MB by email to Human Resources at jobs (at),
JobID: 510122301WAPRO.

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